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LockHunter is a free 64/32 bit tool to delete files blocked by any processes

http://lockhunter.com/

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There are several file unlocker tools for Windows.  In the past, I've used Unlocker as well as FileAssassin, the latter of which is made by the great Malwarebytes organization.

I was unhappy with FileAssassin because it didn't feature explorer integration.  Unlocker was good but always felt a little off to me, and even though it seemed to work it always seemed a bit Windows-98ish to me and I wanted something better.

I'm currently trying LockHunter and we'll see how it fits the bill.